Studies in man with cold‐recombinant influenza virus (h1n1) live vaccines
Identifieur interne : 002844 ( Main/Exploration ); précédent : 002843; suivant : 002845Studies in man with cold‐recombinant influenza virus (h1n1) live vaccines
Auteurs : P. Reeve ; Batia Gerendas ; A. Moritz E. Liehl ; C. Kunz H. Hofmann ; H. F. MaassabSource :
- Journal of Medical Virology [ 0146-6615 ] ; 1980.
Abstract
Two cold‐recombinant influenza A (H1N1) viruses were tested in several groups of human volunteers. Only minor clinical symptoms were seen and no febrile reactions occurred. With serologically primed individuals virus shedding was low, but a high proportion showed rises in serum antibody levels after vaccination and mean titres were high. With serologically unprimed volunteers shedding was high, about 75% yielding viruses but only at low titres and for a short duration. No revertant viruses were found and there was no evidence of transmission to potentially susceptible individuals housed in close contact to the vaccinees. Serum antibody responses with unprimed volunteers were, however, low. Only about one half showed increases in serum antibody titres after vaccination and mean titres were low. Nevertheless, challenge with live attenuated virus indicated a high degree of protection based on virological evidence of infection.
Url:
DOI: 10.1002/jmv.1890060110
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000304
- to stream Istex, to step Curation: 000304
- to stream Istex, to step Checkpoint: 001458
- to stream Main, to step Merge: 002991
- to stream Main, to step Curation: 002844
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Studies in man with cold‐recombinant influenza virus (h1n1) live vaccines</title><author><name sortKey="Reeve, P" sort="Reeve, P" uniqKey="Reeve P" first="P." last="Reeve">P. Reeve</name></author><author><name sortKey="Gerendas, Batia" sort="Gerendas, Batia" uniqKey="Gerendas B" first="Batia" last="Gerendas">Batia Gerendas</name></author><author><name sortKey="E Liehl, A Moritz" sort="E Liehl, A Moritz" uniqKey="E Liehl A" first="A. Moritz" last="E. Liehl">A. Moritz E. Liehl</name></author><author><name sortKey="H Hofmann, C Kunz" sort="H Hofmann, C Kunz" uniqKey="H Hofmann C" first="C. Kunz" last="H. Hofmann">C. Kunz H. Hofmann</name></author><author><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F72141589803100C229BD5AFE85D8BCCA7F46638</idno><date when="1980" year="1980">1980</date><idno type="doi">10.1002/jmv.1890060110</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-C2ZM06JG-0/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000304</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000304</idno><idno type="wicri:Area/Istex/Curation">000304</idno><idno type="wicri:Area/Istex/Checkpoint">001458</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001458</idno><idno type="wicri:doubleKey">0146-6615:1980:Reeve P:studies:in:man</idno><idno type="wicri:Area/Main/Merge">002991</idno><idno type="wicri:Area/Main/Curation">002844</idno><idno type="wicri:Area/Main/Exploration">002844</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Studies in man with cold‐recombinant influenza virus (h1n1) live vaccines</title><author><name sortKey="Reeve, P" sort="Reeve, P" uniqKey="Reeve P" first="P." last="Reeve">P. Reeve</name><affiliation><wicri:noCountry code="subField">(H.F.M.)</wicri:noCountry></affiliation></author><author><name sortKey="Gerendas, Batia" sort="Gerendas, Batia" uniqKey="Gerendas B" first="Batia" last="Gerendas">Batia Gerendas</name><affiliation><wicri:noCountry code="subField">(H.F.M.)</wicri:noCountry></affiliation></author><author><name sortKey="E Liehl, A Moritz" sort="E Liehl, A Moritz" uniqKey="E Liehl A" first="A. Moritz" last="E. Liehl">A. Moritz E. Liehl</name><affiliation><wicri:noCountry code="subField">(H.F.M.)</wicri:noCountry></affiliation></author><author><name sortKey="H Hofmann, C Kunz" sort="H Hofmann, C Kunz" uniqKey="H Hofmann C" first="C. Kunz" last="H. Hofmann">C. Kunz H. Hofmann</name><affiliation><wicri:noCountry code="subField">(H.F.M.)</wicri:noCountry></affiliation></author><author><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField">England===</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">6</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="75">75</biblScope><biblScope unit="page" to="83">83</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1980">1980</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Two cold‐recombinant influenza A (H1N1) viruses were tested in several groups of human volunteers. Only minor clinical symptoms were seen and no febrile reactions occurred. With serologically primed individuals virus shedding was low, but a high proportion showed rises in serum antibody levels after vaccination and mean titres were high. With serologically unprimed volunteers shedding was high, about 75% yielding viruses but only at low titres and for a short duration. No revertant viruses were found and there was no evidence of transmission to potentially susceptible individuals housed in close contact to the vaccinees. Serum antibody responses with unprimed volunteers were, however, low. Only about one half showed increases in serum antibody titres after vaccination and mean titres were low. Nevertheless, challenge with live attenuated virus indicated a high degree of protection based on virological evidence of infection.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="E Liehl, A Moritz" sort="E Liehl, A Moritz" uniqKey="E Liehl A" first="A. Moritz" last="E. Liehl">A. Moritz E. Liehl</name><name sortKey="Gerendas, Batia" sort="Gerendas, Batia" uniqKey="Gerendas B" first="Batia" last="Gerendas">Batia Gerendas</name><name sortKey="H Hofmann, C Kunz" sort="H Hofmann, C Kunz" uniqKey="H Hofmann C" first="C. Kunz" last="H. Hofmann">C. Kunz H. Hofmann</name><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name><name sortKey="Reeve, P" sort="Reeve, P" uniqKey="Reeve P" first="P." last="Reeve">P. Reeve</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002844 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002844 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:F72141589803100C229BD5AFE85D8BCCA7F46638
|texte= Studies in man with cold‐recombinant influenza virus (h1n1) live vaccines
}}
| This area was generated with Dilib version V0.6.33. |  |